JOURNAL ARTICLE

Impact of Pneumococcal Conjugate Vaccines on Otitis Media among American Indian/Alaska Native Children in the Southwest United States.

  • Published In: Journal of the Pediatric Infectious Diseases Society, 2025, v. 14, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sergent, Victoria M; Sutcliffe, Catherine G; Yazzie, Del; Brasinikas, George; Brown, Laura B; Christensen, Loretta; Clichee, Demetria; Damon, Shawnell; Dixon, Sheri L; Grant, Lindsay R; Harker-Jones, Marcella; McAuley, James B; Montanez, Pierrette; Riley, Dennie Parker; Reasonover, Alisa; Rice, Amy; Romancito, Eugene; Salabye, Charis; Simons-Petrusa, Brenna; Tenequer, Valerie L 3 of 3

Abstract

This article evaluates the impact of pneumococcal conjugate vaccines (PCVs) on pneumococcal otitis media (OM) among American Indian/Alaska Native (AI/AN) children under five years old living in Navajo Nation and White Mountain Apache Tribal lands. During the PCV7 era (2000–2009), vaccine-type OM cases declined significantly, but in the PCV13 era (2010–2019), vaccine-type OM—primarily caused by serotypes 3, 19A, and 19F—persisted despite high vaccine coverage. The study suggests that while PCVs have reduced invasive pneumococcal disease, their protection against pneumococcal OM is more limited, potentially due to higher antibody requirements for mucosal protection and socioeconomic factors affecting these communities. The findings highlight the need for improved vaccine formulations or additional interventions to address persistent pneumococcal OM in AI/AN children.

Additional Information

  • Source:Journal of the Pediatric Infectious Diseases Society. 2025/03, Vol. 14, Issue 3, p1
  • Document Type:Article
  • Subject Area:Agriculture and Agribusiness
  • Publication Date:2025
  • ISSN:2048-7193
  • DOI:10.1093/jpids/piaf013
  • Accession Number:184297340
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