JOURNAL ARTICLE

Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.

  • Published In: Brain: A Journal of Neurology, 2023, v. 146, n. 10. P. 4033 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Fuller, Alice M; Luiz, Ana; Tian, Naxi; Arcangeletti, Manuel; Iseppon, Federico; Sexton, Jane E; Millet, Queensta; Caxaria, Sara; Ketabi, Niloofar; Celik, Petek; Wood, John N; Sikandar, Shafaq 3 of 3

Abstract

This article investigates the role of parvalbumin (PV)-expressing proprioceptive sensory neurons in modulating pain through a peripheral gate control mechanism within dorsal root ganglia (DRG). Using a genetic ablation approach in mice to delete PV-positive sensory neurons, the study demonstrates increased nociceptor excitability at the DRG soma, enhanced action potential firing in spinal cord wide dynamic range neurons, and heightened behavioral sensitivity to mechanical and thermal noxious stimuli. The findings indicate that PV-expressing sensory neurons exert tonic inhibition on nociceptors via GABAergic signaling within the DRG, supporting an extension of Melzack and Wall's gate control theory to include peripheral sensory ganglia. This peripheral inhibitory mechanism may represent a novel target for pain modulation outside the central nervous system.

Additional Information

  • Source:Brain: A Journal of Neurology. 2023/10, Vol. 146, Issue 10, p4033
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2023
  • ISSN:0006-8950
  • DOI:10.1093/brain/awad182
  • Accession Number:172872528
  • Copyright Statement:Copyright of Brain: A Journal of Neurology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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