JOURNAL ARTICLE

AI reveals how sperm sticks to egg during fertilization.

  • Published In: Sciencemag.org, 2024. P. N.PAG 1 of 3

  • Database: Applied Science & Technology Source Ultimate 2 of 3

  • Authored By: Offord, Catherine 3 of 3

Abstract

Two recent studies have used artificial intelligence technology to identify a complex of three proteins on the head of sperm that allows it to lock onto the surface of an egg cell during fertilization. The research, published in Cell and eLife, spans zebrafish, mouse, and human proteins, suggesting a high level of conservation in how sperm stick to eggs across vertebrates. While the findings could have clinical implications for infertility and contraception research, further studies are needed to confirm the natural formation of the sperm trimer on mammalian sperm and its binding to mammalian eggs. [Extracted from the article]

Additional Information

  • Source:Sciencemag.org. 2024/10, pN.PAG
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2024
  • Accession Number:180360564
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