JOURNAL ARTICLE

B - 65 Adolescent Cortico-Limbic Connectivity Mediates Associations between Internalizing Symptomology and Subsequent Neurocognitive Performance.

  • Published In: Archives of Clinical Neuropsychology, 2024, v. 39, n. 7. P. 1158 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shankula, Chase A; Navarro, Gabriella Y; Stinson, Elizabeth A; Lisdah, Krista M 3 of 3

Abstract

This article examines how cortico-limbic connectivity, specifically between the Cingulo-Opercular network (CON) and limbic regions (bilateral hippocampus and amygdala), mediates the relationship between internalizing symptoms (anxiety, depression, somatic complaints) in late childhood and neurocognitive performance in early adolescence. Using data from 2,668 youth in the Adolescent Brain Cognitive Development study, the authors found that increased anxiety and somatic symptoms predicted reduced CON-limbic connectivity, which in turn fully mediated the negative impact of these symptoms on working memory and partially mediated effects on attention. Depression did not significantly affect connectivity. These findings suggest that CON-limbic hypoconnectivity may underlie the link between internalizing behaviors and poorer executive functioning during adolescent development.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2024/10, Vol. 39, Issue 7, p1158
  • Document Type:Abstract
  • Subject Area:Anatomy and Physiology
  • Publication Date:2024
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acae067.226
  • Accession Number:184163517
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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