JOURNAL ARTICLE

Weight-based vs fixed dosing of darbepoetin alfa for anemia following kidney transplantation.

  • Published In: American Journal of Health-System Pharmacy, 2023, v. 80, n. 21. P. 1542 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Solis, Jonathan; Wilson, Nicole; Sam, Teena; Ma, Tsung-Wei; Yango, Angelito; Fischbach, Bernard; Kataria, Ann D 3 of 3

Abstract

This article focuses on comparing weight-based versus fixed dosing strategies of darbepoetin alfa, an erythropoietin-stimulating agent, for treating post-transplantation anemia (PTA) in kidney transplant recipients. In a retrospective cohort study of 110 patients, weight-based dosing at 0.45 μg/kg resulted in similar rates of achieving a hemoglobin concentration of at least 10 g/dL without blood transfusion by 12 weeks compared to a fixed dose of 200 μg, but with significantly lower cumulative darbepoetin alfa exposure and potential cost savings. Safety outcomes, including serious adverse events and mortality at six months, were comparable between the two dosing approaches. These findings suggest that weight-based dosing of darbepoetin alfa is a safe, effective, and potentially more economical option for managing PTA in this population.

Additional Information

  • Source:American Journal of Health-System Pharmacy. 2023/11, Vol. 80, Issue 21, p1542
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2023
  • ISSN:1079-2082
  • DOI:10.1093/ajhp/zxad163
  • Accession Number:173238386
  • Copyright Statement:Copyright of American Journal of Health-System Pharmacy is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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