JOURNAL ARTICLE

New Findings in Depression Described by Sarita Thakran and Co-Researchers (Association of endogenous hormones with major depressive disorder phenotype: A systematic review and meta-analysis of drug-free case and control cross-sectional study).

Published In: Mental Health Weekly Digest, 2025. P. 664 1 of 2
Database: Psychology Source 2 of 2

Abstract

The article discusses a meta-analysis examining the biological underpinnings of Major Depressive Disorder (MDD), highlighting the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and other hormonal changes associated with the condition. The research indicates that MDD patients show significantly elevated cortisol, ACTH, b-endorphin, and norepinephrine levels, while hormones from the hypothalamic-pituitary-thyroid/gonadal (HPT/G) axis are reduced. Additionally, the study notes variations in hormonal markers across different MDD subtypes, suggesting a need for further research to clarify their roles in this complex disorder. The findings emphasize the importance of understanding endocrine changes in MDD to enhance treatment approaches. [Extracted from the article]

Additional Information

Source:Mental Health Weekly Digest. 2025/12, p664
Document Type:Article
Subject Area:Anatomy and Physiology
Publication Date:2025
ISSN:1543-6616
Accession Number:189559961
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