JOURNAL ARTICLE

(008) Chronic High Fat Diet Decreases Vaginal Smooth Muscle Tone but does not Affect Pelvic Floor Skeletal Muscle in Mice.

  • Published In: Journal of Sexual Medicine, 2023, v. 20. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Burleson, L; Odom, M; Amorese, A; Spangenburg, E; Hannan, J 3 of 3

Abstract

This study investigates the effects of a chronic high fat diet (HFD) on vaginal smooth muscle tone and pelvic floor skeletal muscle in female mice, focusing on implications for pelvic organ prolapse (POP) and female sexual dysfunction (FSD). Results show that HFD decreases adrenergic-mediated contraction and increases relaxation of vaginal smooth muscle, indicating reduced muscle tone, while the iliococcygeus pelvic floor skeletal muscle's force, fatigue, fiber type composition, and size remain unaffected. These findings suggest that obesity-induced POP may be linked to weakened vaginal smooth muscle function rather than changes in pelvic skeletal muscle, highlighting a potential mechanism contributing to FSD.

Additional Information

  • Source:Journal of Sexual Medicine. 2023/06, Vol. 20, p1
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2023
  • ISSN:1743-6095
  • DOI:10.1093/jsxmed/qdad068.008
  • Accession Number:171965877
  • Copyright Statement:Copyright of Journal of Sexual Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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