JOURNAL ARTICLE

The keratin cytoskeleton emerges as a regulator of mitochondria in the colonic epithelium.

  • Published In: American Journal of Physiology: Gastrointestinal & Liver Physiology, 2024, v. 327, n. 5. P. G699 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Dixit, Michelle; Burclaff, Joseph 3 of 3

Abstract

The article explores the role of the keratin cytoskeleton in regulating mitochondria in the colonic epithelium. It discusses how changes in mitochondrial function impact cellular processes in the intestine and colon, such as metabolism, injury response, and apoptosis. The study by Nyström et al. demonstrates that keratin filaments, specifically type II keratin K8, play a crucial role in regulating mitochondrial structure, dynamics, and metabolism in colonocytes, shedding light on potential implications for gastrointestinal diseases and therapeutic development. [Extracted from the article]

Additional Information

  • Source:American Journal of Physiology: Gastrointestinal & Liver Physiology. 2024/11, Vol. 327, Issue 5, pG699
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2024
  • ISSN:0193-1857
  • DOI:10.1152/ajpgi.00228.2024
  • Accession Number:180795379
  • Copyright Statement:Copyright of American Journal of Physiology: Gastrointestinal & Liver Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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