JOURNAL ARTICLE

L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb.

  • Published In: Toxicology & Industrial Health, 2023, v. 39, n. 2. P. 115 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Dehghani, Ali; Pourjafari, Farimah; Koohkan, Faeze; Haghpanh, Tahereh; Pourjafari, Fahimeh; Sheibani, Vahid; Afarinesh, Mohammad Reza 3 of 3

Abstract

This article focuses on the neurotoxic effects of the fungicide mancozeb and the protective role of the antioxidant L-carnitine in rats. Mancozeb exposure decreased locomotor activity and impaired sensorimotor gating, as measured by reductions in the acoustic startle response (ASR) amplitude and prepulse inhibition (PPI), suggesting potential risks for cognitive disorders. Conversely, L-carnitine administration increased locomotor activity and PPI, and co-administration with mancozeb attenuated the fungicide’s adverse effects, likely through its antioxidant and mitochondrial protective properties. The study highlights mancozeb’s impact on neurotransmitter balance, thyroid function, and oxidative stress, while proposing L-carnitine as a neuroprotective agent against such toxicity.

Additional Information

  • Source:Toxicology & Industrial Health. 2023/02, Vol. 39, Issue 2, p115
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2023
  • ISSN:0748-2337
  • DOI:10.1177/07482337231151739
  • Accession Number:161686715
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