JOURNAL ARTICLE

Volatile organic metabolites to predict clinical response in patients with inflammatory bowel diseases treated with biological therapy.

  • Published In: Minerva Biotechnology & Biomolecular Research, 2024, v. 36, n. 4. P. 195 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: RIBALDONE, Davide G.; AREZZO, Alberto; CARDENIA, Vladimiro; CAVIGLIA, Gian Paolo; ABATE, Maria L.; RADICE, Elisabetta; SARACCO, Giorgio M.; ASTEGIANO, Marco; MORINO, Mario 3 of 3

Abstract

This article investigates the use of fecal volatile organic metabolites (VOMs) measured by gas chromatography/mass spectrometry (GC/MS) to predict clinical response in patients with inflammatory bowel diseases (IBD), specifically Crohn’s disease (CD) and ulcerative colitis (UC), undergoing biological therapy with adalimumab or vedolizumab. The study found that baseline levels of methyl butanoate could predict clinical response after 12 months of treatment, while methyl indole and octenol differentiated UC from CD and correlated with inflammation markers (CRP and calprotectin). Additionally, methylbutanal was associated with CD, particularly ileal involvement. VOMs appeared independent of patient age, sex, smoking status, and disease duration, suggesting potential as noninvasive biomarkers for disease characterization and therapy monitoring in IBD.

Additional Information

  • Source:Minerva Biotechnology & Biomolecular Research. 2024/12, Vol. 36, Issue 4, p195
  • Document Type:Article
  • Subject Area:Anatomy and Physiology
  • Publication Date:2024
  • ISSN:2724-542X
  • DOI:10.23736/S2724-542X.24.03118-3
  • Accession Number:181431658
  • Copyright Statement:Copyright of Minerva Biotechnology & Biomolecular Research is the property of Edizioni Minerva Medica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.