Kaempferitrin modulates AMPK phosphorylation and PEPCK expression in the liver after a short-term high-fat, high-sucrose diet intervention in mice.

This article investigates the effects of kaempferitrin, a glycosylated flavonoid found in certain Brazilian plants, on glycemic homeostasis in mice subjected to a short-term (3, 6, or 24 hours) high-fat, high-sucrose (HFHS) diet. While kaempferitrin did not prevent glucose intolerance induced by the HFHS diet after 24 hours, it significantly reduced hepatic expression of phosphoenolpyruvate carboxykinase (PEPCK), a key gluconeogenic enzyme, and modulated AMP-activated protein kinase (AMPK) phosphorylation levels in the liver. These findings suggest that kaempferitrin influences hepatic metabolic pathways related to energy homeostasis but does not acutely improve glucose tolerance under these dietary conditions. The study highlights kaempferitrin's potential as a candidate for further research in diabetes treatment, emphasizing the need for longer-term and multi-organ investigations.