Decoding lysosome communication.
Published In: Science (pre-March 2025), 2025, v. 387, n. 6732. P. 359 1 of 3
Database: Academic Search Ultimate 2 of 3
Authored By: Pullamsetti, Soni Savai; Sava, Rajkumar 3 of 3
Abstract
The article in the journal "Science" discusses the connection between lysosomes and pulmonary arterial hypertension (PAH). Researchers found that disrupted lysosomal activity is linked to altered sterol metabolism, vascular inflammation, and disease severity in PAH. The study highlights the importance of understanding lysosome communication with other organelles in health and disease to develop new preventive and therapeutic strategies for various conditions, including cardiovascular disease and cancer. The findings suggest that targeting lysosomal dysfunction with metabolic and epigenetic modulators could be a potential avenue for therapeutic intervention. [Extracted from the article]
Additional Information
- Source:Science (pre-March 2025). 2025/01, Vol. 387, Issue 6732, p359
- Document Type:Article
- Subject Area:Anatomy and Physiology
- Publication Date:2025
- ISSN:0036-8075
- DOI:10.1126/science.adv1201
- Accession Number:182419194
- Copyright Statement:Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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