JOURNAL ARTICLE

Analysis of 132 submandibular salivary glands using the Randox Evidence Investigator and Randox DOA ULTRA WB array.

  • Published In: Journal of Analytical Toxicology, 2024, v. 48, n. 8. P. 591 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Adamczyk, Jessica L; Prahlow, Joseph A; Grieger-Nimmo, Roberta; Kundu, Rajeswari; Jones, Prentiss 3 of 3

Abstract

This article evaluates the use of submandibular salivary gland tissue as an alternative postmortem specimen for preliminary drug screening when blood samples are unavailable due to decomposition, exsanguination, or embalming. Using the Randox Evidence Investigator instrument and the Randox DOA (Drugs of Abuse) Ultra Whole Blood Array, 132 paired submandibular salivary gland tissue and postmortem whole blood specimens were analyzed for 21 drug immunoassays. Results showed substantial to almost perfect agreement for 16 of 18 analytes, including many opioids and common drugs of abuse, while cannabinoids demonstrated only slight agreement. The study suggests that submandibular salivary gland tissue could be integrated into forensic toxicology workflows to provide preliminary screening results, though confirmatory testing remains necessary.

Additional Information

  • Source:Journal of Analytical Toxicology. 2024/10, Vol. 48, Issue 8, p591
  • Document Type:Article
  • Subject Area:Applied Sciences
  • Publication Date:2024
  • ISSN:0146-4760
  • DOI:10.1093/jat/bkae071
  • Accession Number:180533334
  • Copyright Statement:Copyright of Journal of Analytical Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.