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CD8+ T‐cell efficiency is affected by the form of membrane lipids in lipid rafts.

  • Published In: Allergy, 2024, v. 79, n. 9. P. 2577 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Piperakis, Artemios 3 of 3

Abstract

This article discusses the role of membrane lipids in T-cell activation and differentiation. The authors found that the saturation levels of acyl chains in membrane lipids play a crucial role in T-cell activation. They also discovered that the availability of glucose and increased glycolytic metabolism are important in regulating the signaling of phosphatidylinositol (PI) and phosphatidylinositol bisphosphate (PIP2). Additionally, the authors propose that manipulating lipid biosynthesis could be a potential strategy for cancer therapy, as saturated PI synthesis was elevated in tumor-infiltrating lymphocytes (TILs) and correlated with positive responses to checkpoint inhibitor treatment in melanoma patients. [Extracted from the article]

Additional Information

  • Source:Allergy. 2024/09, Vol. 79, Issue 9, p2577
  • Document Type:Article
  • Subject Area:Biology
  • Publication Date:2024
  • ISSN:0105-4538
  • DOI:10.1111/all.16176
  • Accession Number:179392236
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