JOURNAL ARTICLE

Findings from Washington University School of Medicine in Lewy Body Disease Reported (Use of Amplified Lewy Body Dementia Fibrils and Autoradiography to Characterize Binding of Radioligand Tg-1-90B to Alpha-Synuclein Fibrils in Postmortem Brain...).

  • Published In: Mental Health Weekly Digest, 2025. P. 343 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article focuses on research related to Lewy Body Disease (LBD) and its connection to alpha-synuclein (Asyn) fibrils, which are implicated in both Parkinson's disease (PD) and LBD. Conducted by researchers at Washington University School of Medicine in St. Louis, Missouri, the study explores the development of a Positron Emission Tomography (PET) tracer, Tg-1-90B, designed to quantify Asyn fibrils, potentially enhancing diagnostic accuracy and tracking disease progression. While Tg-1-90B shows promise in binding to Asyn fibrils in PD tissue, it also binds to amyloid-beta fibrils in Alzheimer's disease, indicating a need for further optimization. The research is supported by organizations including the National Institutes of Health and the Michael J. Fox Foundation for Parkinson's Disease. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2025/10, p343
  • Document Type:Article
  • Subject Area:Biology
  • Publication Date:2025
  • ISSN:1543-6616
  • Accession Number:188416190
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