JOURNAL ARTICLE

Meiosis in budding yeast.

  • Published In: Genetics, 2023, v. 225, n. 2. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Börner, G. Valentin; Hochwagen, Andreas; MacQueen, Amy J. 3 of 3

Abstract

The article provides a comprehensive overview of meiosis in the budding yeast *Saccharomyces cerevisiae*, a key model organism for studying meiotic chromosome metabolism. It details the specialized meiotic program that reduces chromosome number by half through two consecutive divisions, emphasizing unique processes such as homolog pairing, synaptonemal complex (SC) assembly, programmed DNA double-strand break (DSB) formation, and crossover recombination. The review highlights the molecular mechanisms underlying these events, including the roles of cohesin complexes, recombinases Rad51 and Dmc1, and the ZMM protein group in coordinating recombination and SC formation. Additionally, it discusses regulatory pathways controlling meiotic progression, checkpoint functions monitoring recombination, and mechanisms ensuring accurate chromosome segregation, while noting the conservation of these processes across eukaryotes and the utility of yeast for dissecting their molecular details.

Additional Information

  • Source:Genetics. 2023/10, Vol. 225, Issue 2, p1
  • Document Type:Article
  • Subject Area:Biology
  • Publication Date:2023
  • ISSN:0016-6731
  • DOI:10.1093/genetics/iyad125
  • Accession Number:172788828
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