JOURNAL ARTICLE

A new phthalide derivative from the mushroom Cyclocybe cf. erebia culture filtrate affects the phase of circadian rhythms in mouse fibroblasts.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2025, v. 89, n. 3. P. 354 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kobayashi, Yusei; Lu, Yuanyuan; Li, Nan; Endo, Naoki; Sotome, Kozue; Ueno, Kotomi; Tahara, Yu; Ishihara, Atsushi 3 of 3

Abstract

The article focuses on the discovery and characterization of cyclocybelide, a novel phthalide derivative isolated from the culture filtrate of the mushroom Cyclocybe cf. erebia, which modulates circadian rhythms in mouse fibroblasts. Cyclocybelide was found to advance the phase of circadian rhythms regardless of treatment timing, distinguishing it from previously identified mushroom-derived compounds that affect circadian amplitude or period. Structural analysis revealed that phthalide derivatives with hydroxy or methoxy substitutions on the benzene ring exhibit phase-advancing activity, suggesting potential for developing new regulators of circadian rhythm disorders. The study highlights the unique bioactivity of cyclocybelide and underscores the value of mushrooms as sources of circadian rhythm modulators.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2025/03, Vol. 89, Issue 3, p354
  • Document Type:Article
  • Subject Area:Biology
  • Publication Date:2025
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbae187
  • Accession Number:184192908
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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