JOURNAL ARTICLE

Oxidative DNA damage of lambda-cyhalothrin in model vertebrate organism.

  • Published In: Toxicology & Industrial Health, 2025, v. 41, n. 3. P. 186 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Şemsi, Rabia; Eser, Burcu; Koçak, Gülsüm; Gül, Göktuğ; Yüce, Pınar Arslan; Günal, Aysel Çağlan; Dinçel, Aylin Sepici 3 of 3

Abstract

This article focuses on the toxic effects of lambda-cyhalothrin (LCH), a synthetic pyrethroid insecticide, on DNA integrity in zebrafish (Danio rerio) as a model aquatic organism. The study exposed zebrafish to 0.1 mg/L LCH for 24 and 72 hours and measured oxidative DNA damage using 8-hydroxy-2-deoxyguanosine (8-OHdG) levels via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results showed a significant increase in 8-OHdG concentrations after 72 hours of exposure compared to controls, indicating that LCH induces oxidative DNA damage in zebrafish. The findings highlight potential adverse effects of LCH on non-target aquatic species and underscore the need for further research on its environmental impact and mechanisms of toxicity.

Additional Information

  • Source:Toxicology & Industrial Health. 2025/03, Vol. 41, Issue 3, p186
  • Document Type:Article
  • Subject Area:Biology
  • Publication Date:2025
  • ISSN:0748-2337
  • DOI:10.1177/07482337251316771
  • Accession Number:183272748
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