JOURNAL ARTICLE

Anti-inflammatory diterpenoids from the brown alga Dictyota coriacea.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2025, v. 89, n. 2. P. 224 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shiiba, Nozomi; Kumagai, Momochika; Endo, Hikaru; Tsuruta, Tomoki; Nishikawa, Keisuke; Morimoto, Yoshiki 3 of 3

Abstract

This article focuses on the isolation and anti-inflammatory evaluation of diterpenoids from the brown alga Dictyota coriacea. A new xenicane diterpene, 4α-acetoxyisodictyohemiacetal, along with 11 known diterpenoids, were isolated and structurally characterized using spectroscopic methods and electronic circular dichroism (ECD) analysis. The anti-inflammatory activities of these compounds were assessed in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264 cells, where hemiacetal-containing xenicane diterpenoids and dictyol-type diterpenes notably inhibited nitric oxide production and suppressed mRNA expression of inducible nitric oxide synthase, interleukin-6, and cyclooxygenase-2. These findings suggest that diterpenes from D. coriacea may serve as natural anti-inflammatory agents.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2025/02, Vol. 89, Issue 2, p224
  • Document Type:Article
  • Subject Area:Botany
  • Publication Date:2025
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbae163
  • Accession Number:182905882
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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