JOURNAL ARTICLE

Dehydrozingerone enhances the fungicidal activity of glabridin against Saccharomyces cerevisiae and Candida albicans.

  • Published In: Letters in Applied Microbiology, 2023, v. 76, n. 4. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Yamano, Saya; Tsukuda, Yuka; Mizuhara, Naoko; Yamaguchi, Yoshihiro; Ogita, Akira; Fujita, Ken-Ichi 3 of 3

Abstract

This article focuses on the antifungal potential of combining dehydrozingerone, a phenolic compound from Zingiber officinale (ginger), with glabridin, an isoflavan from Glycyrrhiza glabra L. (licorice), to counteract multidrug resistance in fungi. The study demonstrates that dehydrozingerone enhances the antifungal activity of glabridin against Saccharomyces cerevisiae and the human pathogen Candida albicans by suppressing the overexpression of ATP-binding cassette (ABC) transporter genes—specifically PDR1, PDR3, and PDR5—that mediate drug efflux. This suppression reduces the efflux of glabridin, thereby increasing its intracellular accumulation and antifungal efficacy. The findings provide empirical support for plant-based combination therapies targeting multidrug resistance mechanisms in fungi.

Additional Information

  • Source:Letters in Applied Microbiology. 2023/04, Vol. 76, Issue 4, p1
  • Document Type:Article
  • Subject Area:Botany
  • Publication Date:2023
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovad040
  • Accession Number:164203205
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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