JOURNAL ARTICLE

New nitrogen-compounds, penicidones E and F, produced by the fungal strain Oidiodendron sp. FKI-7498.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 1. P. 38 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Rei Miyano; Hirotaka Matsuo; Takayuki Mokudai; Mayuka Higo; Kenichi Nonaka; Yoshimi Niwano; Kazuro Shiomi; Yōko Takahashi; Satoshi Ōmura; Takuji Nakashima 3 of 3

Abstract

This article focuses on the discovery and characterization of two new nitrogen-containing compounds, penicidones E and F, produced by the filamentous fungal strain Oidiodendron sp. FKI-7498 isolated from soil in Tokushima, Japan. Using physicochemical screening guided by the nitrogen rule in mass spectrometry, the compounds were purified and structurally elucidated by mass spectrometry, nuclear magnetic resonance spectroscopy, and chemical modification, revealing a core structure of 3,5-dihydroxy-2-(4-pyridone-3-carbonyl) benzoic acid. Penicidone F demonstrated dose-dependent hydroxyl radical scavenging activity, whereas penicidone E showed little such activity; neither exhibited other significant biological activities. The study highlights Oidiodendron as a potential source of novel natural products distinct from related fungi such as Penicillium.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2023/01, Vol. 87, Issue 1, p38
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2023
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbac184
  • Accession Number:161134557
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