JOURNAL ARTICLE

Enantioselective Synthesis of Chiral γ‐Amino Acid Esters via Photoredox/Nickel‐Catalyzed Aryl‐Aminoalkylation of Alkenes.

  • Published In: Chinese Journal of Chemistry, 2025, v. 43, n. 15. P. 1862 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ye, Fu; Xu, Youzhi; Zheng, Songlin; Huang, Genping; Yuan, Weiming 3 of 3

Abstract

Comprehensive Summary: Chiral γ‐amino acids are among the most valuable and ubiquitous structural units in natural products, pharmaceuticals and many physiologically active compounds. Herein, we demonstrate a convenient synthetic approach to chiral γ‐amino acid structures via an asymmetric aryl‐aminoalkylation of alkenes enabled by a dual photoredox/nickel catalysis. Taking advantage of the mild and redox‐neutral condition, high levels of enantiocontrol of α‐carbonyl benzylic stereocenters are obtained. Experimental and computational mechanistic studies were performed to gain insights into the mechanism and origin of enantioselectivity. The results reveal that the reaction follows a Ni(0)/Ni(I)/Ni(III)/Ni(I) catalytic cycle and C–X bond oxidative addition is the enantiodetermining step. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Chinese Journal of Chemistry. 2025/08, Vol. 43, Issue 15, p1862
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1001-604X
  • DOI:10.1002/cjoc.70060
  • Accession Number:187572107
  • Copyright Statement:Copyright of Chinese Journal of Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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