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The Role of Hydrogen Bonds in Thermally Responsive Crystallization‐Driven Template Autocatalysis.

  • Published In: Angewandte Chemie, 2024, v. 136, n. 27. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wu, Huimin; Chen, Qing‐Xuan; Su, Yang; Chen, Zhen 3 of 3

Abstract

Autocatalysis has been recognized to be involved in the emergence of life and intrinsic to biomolecular replication. Recently, an efficient template autocatalysis driven by solvent‐free crystallization has been reported. Herein, we unveil the role of intermolecular hydrogen bonds formed by amides in crystallization‐driven template autocatalysis (CDTA), which involves the autocatalytic activity, template selectivity, and thermal responsiveness. We found that the thermal‐induced cis‐trans isomerization of amides possibly affects the H‐bonding‐mediated template ability of products for autocatalytic transformation. As a result, CDTA can be reversibly inhibited and activated by tuning the reaction temperatures. Our work sheds light on the significance of noncovalent H‐bonding interactions in artificial self‐replicators. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Angewandte Chemie. 2024/07, Vol. 136, Issue 27, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2024
  • ISSN:0044-8249
  • DOI:10.1002/ange.202404838
  • Accession Number:178279938
  • Copyright Statement:Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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