JOURNAL ARTICLE

Continuous Flow N‐methylation of Morpholine and Aniline Catalyzed by Mesoporous Al‐SBA‐15.

  • Published In: Asian Journal of Organic Chemistry, 2025, v. 14, n. 5. P. 1 1 of 3

  • Database: Applied Science & Technology Source Ultimate 2 of 3

  • Authored By: Sanoja‐López, Kelvin A.; Nope, Eliana; Luque, Rafael 3 of 3

Abstract

A continuous flow alkylation process is disclosed to synthesize N‐methylated derivatives of aniline and morpholine, compounds vital to the pharmaceutical, agrochemical, and polymer industries, using a mesoporous Al‐SBA‐15 catalyst. Conversions reached up to 99 % with almost complete selectivity for monoalkylated products under optimized temperature, pressure, and flow conditions. Compared to traditional batch methods, the continuous flow system enabled precise control of reaction parameters, significantly enhancing efficiency, reducing solvent use, and minimizing by‐product formation. The results demonstrate the process's feasibility for industrial applications, emphasizing its potential for more sustainable, cost‐effective large‐scale production and the role of continuous flow systems in developing safer, scalable, and environmentally friendly chemical processes. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Asian Journal of Organic Chemistry. 2025/05, Vol. 14, Issue 5, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:21935807
  • DOI:10.1002/ajoc.202400760
  • Accession Number:185186745
  • Copyright Statement:Copyright of Asian Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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