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C−C Coupling of Ketones with Ethanol and Methanol Enabled by Nickel Catalysis.

  • Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 17. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sk, Motahar; Ghosh, Adrija; Mohan Kabadwal, Lalit; Banerjee, Debasis 3 of 3

Abstract

Herein, we have reported the application of C1 and C2 alcohols for the C−C coupling with ketones enabled by nickel. De‐hydrogenation of ethanol took place under relatively milder conditions (100 °C) and resulted the functionalized 1,5‐diketones with acetophenone derivatives in one pot operation. Further, multi‐component strategy using ketones, and methanol in combination with various nitrogen‐based nucleophiles resulted the α‐aminomethylation under nickel‐catalysis. For a synthetic application, a series of tetra‐substituted pyridines have been demonstrated. Preliminary mechanistic investigations, control experiments and deuterium labelling studies were established the interrupted borrowing hydrogen (I‐BH) strategy. The catalytic transformations are highly sustainable and released water and dihydrogen as by products. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Organic Chemistry. 2025/05, Vol. 28, Issue 17, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1434-193X
  • DOI:10.1002/ejoc.202500067
  • Accession Number:186458366
  • Copyright Statement:Copyright of European Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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