JOURNAL ARTICLE

Ecofriendly Chromatographic Assay of Metformin Combinations; Content Uniformity Tests and Toxicity Profiling.

  • Published In: Journal of Chromatographic Science, 2024, v. 62, n. 6. P. 526 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Emam, Aml A; Abdelaleem, Eglal A; Magdy, Fatma; Gouda, Ahmed M; Abdallah, Fatma F 3 of 3

Abstract

The article focuses on the development and validation of a green, accurate, and precise high-performance thin-layer chromatography (HPTLC) method for the simultaneous determination of metformin, glipizide, and sitagliptin—three antidiabetic drugs—along with metformin's potential toxic impurities melamine and cyanoguanidine. Using silica gel HPTLC plates and a specific mobile phase, the method achieved effective separation with high sensitivity, linearity, and specificity, validated according to International Council for Harmonisation (ICH) guidelines. The method was successfully applied to commercial pharmaceutical tablets (Janumet® and Engilor®) without interference from excipients, and its environmental impact was assessed positively using four greenness evaluation tools. This approach offers a reliable and ecofriendly option for routine quality control of these drugs and their impurities.

Additional Information

  • Source:Journal of Chromatographic Science. 2024/07, Vol. 62, Issue 6, p526
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2024
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmad026
  • Accession Number:178383406
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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