Electrochemical study of oxidized hyaluronic acid grafted with aniline tetramer Bletilla striata polysaccharide hydrogel wound dressings.

This article focuses on the development and characterization of a conductive hydrogel based on Bletilla striata polysaccharide (Bletilla gum) crosslinked with hydroxypropyl chitosan and an electroactive copolymer of oxidized hyaluronic acid grafted with aniline tetramer (OHA-AT). The resulting hydrogel exhibits combined bioactivity—including antibacterial, coagulation-promoting, and biocompatible properties—and electrical conductivity suitable for microcurrent stimulation, making it a promising candidate for biomedical applications such as wound dressings. The study details the synthesis, structural and electrochemical characterization, and in vitro evaluation of the hydrogel's mechanical properties, swelling, degradation, drug release, antibacterial activity, protein adsorption, hemostatic performance, and cytocompatibility. Findings indicate that increasing the aniline tetramer content enhances conductivity, porosity, antibacterial effect, and protein adsorption while maintaining good cytocompatibility, although the research is limited to in vitro experiments and suggests further in vivo studies for clinical translation.