JOURNAL ARTICLE

Characterization of Chemical Constituents and Metabolites in Rat Plasma after Oral Administration of Zhi-Zi-Hou-Po Decoction by High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry.

  • Published In: Journal of Chromatographic Science, 2025, v. 63, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shi, Jianyi; Guan, Jiao; Pan, Xu; Feng, Bo; Zhu, Heyun 3 of 3

Abstract

This article focuses on the chemical characterization and metabolic profiling of Zhi-Zi-Hou-Po decoction (ZZHPD), a traditional Chinese medicine prescription used for treating depression. Using a high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method, the study identified 88 chemical constituents in ZZHPD extract and detected 40 compounds—including 29 prototype constituents and 11 metabolites—in rat plasma after oral administration. The main components of ZZHPD were found to be iridoid glycosides, lignans, flavonoids, coumarins, monoterpenoids, crocetins, and organic acids, with glucuronidation and sulfation identified as primary metabolic pathways in rats. These findings provide a foundation for further research into the pharmacodynamic material basis and mechanisms of action of ZZHPD.

Additional Information

  • Source:Journal of Chromatographic Science. 2025/03, Vol. 63, Issue 3, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmaf012
  • Accession Number:184405628
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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