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(3+3)‐Annulation of 2‐Mercaptobenzimidazoles With α‐(Trifluoromethyl)Styrene Under Ultrasonic Irradiation.

  • Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 4. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sohail, Akbar; Ablajan, Keyume; Khan, Shahid Ali 3 of 3

Abstract

A rapid and facile sonochemical route for the [3+3] annulation of 2‐mercapto benzimidazoles with α‐(trifluoromethyl)styrene was reported for the synthesis of fluorinated benzo[4,5]imidazo[2,1‐b][1,3]thiazines. The reaction proceeds through the SN2/SNV pathway while the selective SN2 pathway is completely inhibited. The developed method is effective with a wide range of substrates, tolerating diverse functional groups. The pure products are obtained with high yield (up to 92 %) directly via recrystallization without column chromatography. Furthermore, applying sonochemical methodology reduces the reaction time and eliminates the need for expensive photocatalysts, ligands or oxidants. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Organic Chemistry. 2025/01, Vol. 28, Issue 4, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1434-193X
  • DOI:10.1002/ejoc.202401175
  • Accession Number:183898682
  • Copyright Statement:Copyright of European Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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