NHC‐Free Ketone Synthesis via Radical Coupling Mechanisms.

  • Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 17. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wang, Lifeng; Cai, Yuxing; Huang, Yong 3 of 3

Abstract

Ketone synthesis via radical coupling mechanisms has recently gained significant attention. Traditionally, these methods have relied on N‐heterocyclic carbenes (NHCs) to generate the key ketyl radical intermediate, either through single‐electron reduction of acyl azolium or single‐electron oxidation involving the Breslow intermediate. In this report, we introduce a novel photoredox protocol that directly generates ketyl radicals from stable acyl imidazoles without the need for NHCs. This approach not only simplifies the process, but also demonstrates broad tolerance for various alkyl radical substrates. Additionally, it can be extended to facilitate relay‐radical coupling reactions. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Organic Chemistry. 2025/05, Vol. 28, Issue 17, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1434-193X
  • DOI:10.1002/ejoc.202500011
  • Accession Number:186458357
  • Copyright Statement:Copyright of European Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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