JOURNAL ARTICLE

The phoenix's journey: unravelling muscle acidosis in the exercise pressor reflex.

  • Published In: Journal of Physiology, 2025, v. 603, n. 18. P. 5223 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Butenas, Alec L. E. 3 of 3

Abstract

The article focuses on the role of lactate and hydrogen ions in the exercise pressor reflex, particularly during ischaemic conditions, as investigated in a study using a rat knockout model for myophosphorylase deficiency. The study found that while the absence of lactate and hydrogen ions did not diminish the exercise pressor reflex during freely perfused contractions, these metabolites were crucial for triggering the reflex during acute limb ischaemia. The findings suggest that other metabolites may not play a significant role in exaggerating the reflex response during ischaemia, highlighting the complexity of metabolic interactions involved in this physiological response. Further research is needed to explore the implications of these findings in chronic ischaemic conditions. [Extracted from the article]

Additional Information

  • Source:Journal of Physiology. 2025/09, Vol. 603, Issue 18, p5223
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:0022-3751
  • DOI:10.1113/JP286722
  • Accession Number:188365294
  • Copyright Statement:Copyright of Journal of Physiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.