JOURNAL ARTICLE

Extraordinary 99Mo adsorption: utilizing spray-dried mesoporous alumina for clinical-grade generator development.

  • Published In: Bulletin of the Chemical Society of Japan, 2024, v. 97, n. 10. P. 1 1 of 3

  • Database: Applied Science & Technology Source Ultimate 2 of 3

  • Authored By: Alowasheeir, Azhar; Eguchi, Miharu; Fujita, Yoshitaka; Tsuchiya, Kunihiko; Wakabayashi, Ryutaro; Kimura, Tatsuo; Ariga, Katsuhiko; Hatano, Kentaro; Fukumitsu, Nobuyoshi; Yamauchi, Yusuke 3 of 3

Abstract

The article focuses on the development of clinical-grade molybdenum-99/technetium-99m (⁹⁹Mo/⁹⁹ᵐTc) generators using mesoporous alumina spherical particles synthesized via spray-drying with EOₙPOₘEOₙ self-assembly. These particles demonstrate superior molybdenum adsorption capacities compared to commercially available alumina, with solvent extraction methods yielding the highest adsorption efficiency. A novel tandem column generator employing these mesoporous alumina particles produces technetium-99m with high radionuclidic, radiochemical, and chemical purity, suitable for preparing ⁹⁹ᵐTc-labeled radiopharmaceuticals. The study systematically evaluates surfactant removal methods and confirms the practical feasibility of this approach for clinical-scale generator production.

Additional Information

  • Source:Bulletin of the Chemical Society of Japan. 2024/10, Vol. 97, Issue 10, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2024
  • ISSN:00092673
  • DOI:10.1093/bulcsj/uoae099
  • Accession Number:180607355
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