β‐halovinyl Aldehydes: Multifaceted Versatile Building Blocks In Organic Synthesis.

  • Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 6. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Saini, Paras; Jyoti; Sharma, Pawan K.; Singh, Virender 3 of 3

Abstract

β‐halovinyl aldehydes serve as a valuable building blocks in organic synthesis. These aldo‐x bifunctional building blocks (AXB3s) contain a alkenic double bond (vinyl) as well as a formyl group along with a halogen atom (Cl, Br, I) bonded with the β‐carbon atom of vinyl aldehyde. Owing to the presence of these multiple reactive sites, β‐halovinyl aldehydes act as a suitable precursor for Michael addition, direct addition, addition‐elimination reactions, cross‐coupling reactions, condensation reactions, nucleophilic substitution reactions, domino reactions, MCRs, Diels‐Alder reaction, functional group transformation reactions and enantioselective transformations. Therefore, a comprehensive review on synthetic exploration of β‐halovinyl aldehydes has been carried out for the generation of reactive intermediates and diverse bioactive heterocycles by using various C−C, C−N, C−S and C−O bond forming reactions. In this review, we have assembled the literature from mid‐2007 to Jan 2024. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Organic Chemistry. 2025/02, Vol. 28, Issue 6, p1
  • Document Type:Literature Review
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1434-193X
  • DOI:10.1002/ejoc.202401058
  • Accession Number:183898689
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