JOURNAL ARTICLE

Validation and Collaborative Studies of Headspace Gas Chromatography-Mass Spectrometry for Determination of 1,4-Dioxane in Cosmetic Samples.

  • Published In: Journal of AOAC International, 2024, v. 107, n. 5. P. 795 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lusianti, Erita; Zannah, Nenden Solihatul; Purwaningsih, Sri; Kusuma, Hasti; Hastuti, Agustina A M B; Windarsih, Anjar; Cheah, Nuan Ping; Thongprakaisang, Siriporn; Rohman, Abdul 3 of 3

Abstract

This article focuses on the validation of a static headspace gas chromatography-mass spectrometry (HS GC-MS) method for detecting 1,4-dioxane (1,4-D), a probable human carcinogen and byproduct found at trace levels in cosmetics products. The study optimized and validated the HS GC-MS method for specificity, linearity, limit of detection (LoD), limit of quantification (LoQ), accuracy, and precision, demonstrating its suitability for routine analysis. A collaborative study involving 10 laboratories across four countries confirmed the method's reproducibility and reliability, with recovery rates between 94.6% and 102.1% and relative standard deviations (RSD) from 0.2% to 1.1%. The validated HS GC-MS method offers a fast, minimally preparative, and sensitive approach for quantifying 1,4-D in cosmetics and potentially other sample matrices.

Additional Information

  • Source:Journal of AOAC International. 2024/09, Vol. 107, Issue 5, p795
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2024
  • ISSN:1060-3271
  • DOI:10.1093/jaoacint/qsae056
  • Accession Number:179637351
  • Copyright Statement:Copyright of Journal of AOAC International is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.