JOURNAL ARTICLE

Total Syntheses of Asparenyn, Gobicusin B, and PPAR‐Agonist NNC 61‐4655 Through a FeCl3‐Assisted Electrophilic Fluorine‐Catalyzed 1,3‐Rearrangement of Allylic Alcohols.

  • Published In: Asian Journal of Organic Chemistry, 2025, v. 14, n. 4. P. 1 1 of 3

  • Database: Applied Science & Technology Source Ultimate 2 of 3

  • Authored By: Sun, Hanyang; Han, Hezhen; Yin, Shengbo; Zhang, Shuhao; Lin, Bin; Cheng, Maosheng; Yang, Lu; Liu, Yongxiang 3 of 3

Abstract

A FeCl3‐assisted electrophilic fluorine‐catalyzed 1,3‐rearrangement was developed, characterized by its mild catalytic system and broad substrate scope. The functional group tolerance of this approach was evaluated through a series of allylic alcohols readily prepared in situ from commercially available enones. Various nucleophiles, including water, amides, and Hantzsch esters, were utilized in the reaction. A plausible mechanism was proposed to elucidate the observed transformations, and the versatility of this methodology was demonstrated through the syntheses of asparenyn, gonicusin B, and the PPAR‐agonist NNC 61‐4655. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Asian Journal of Organic Chemistry. 2025/04, Vol. 14, Issue 4, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:21935807
  • DOI:10.1002/ajoc.202400716
  • Accession Number:184573882
  • Copyright Statement:Copyright of Asian Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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