JOURNAL ARTICLE

Chemical and Biosynthetic Evolution of Quadrane and Related Sesquiterpenoids.

  • Published In: European Journal of Organic Chemistry, 2025, v. 28, n. 14. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Song, Yongxiang; Yan, Yan 3 of 3

Abstract

Natural products, with their potent bioactivities and selectivities, significantly benefit human health and agriculture. The evolution of biosynthetic enzymes of natural products has greatly expanded their chemical space relevant to bioactivity. Insights from natural evolution provide valuable guidance for engineering these enzymes to create molecules with novel structures and bioactivities. Recent studies have unveiled an intriguing biosynthetic evolution of fungal‐derived quadrane sesquiterpene scaffolds, indicating evolutionary relationships among sesquiterpene scaffolds such as humulene, caryophyllene, presilphiperfolan‐8‐ol, silphinene, and terrecyclene, rooted in their biosynthetic mechanisms. This review summarizes recent progress in the discovery and biosynthetic characterization of these sesquiterpenoids. These findings illuminate the logic behind the chemical and biosynthetic evolution of sesquiterpenes and offer opportunities to discover new sesquiterpenoids through genome mining. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Organic Chemistry. 2025/04, Vol. 28, Issue 14, p1
  • Document Type:Literature Review
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1434-193X
  • DOI:10.1002/ejoc.202401424
  • Accession Number:185838876
  • Copyright Statement:Copyright of European Journal of Organic Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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