JOURNAL ARTICLE

A Visible Light Driven Nickel Carbonylation Catalyst: The Synthesis of Acid Chlorides from Alkyl Halides.

  • Published In: Angewandte Chemie International Edition, 2023, v. 62, n. 10. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: El Chami, Kristian; Liu, Yi; Belahouane, Mohammed A.; Ma, Yiyang; Lagueux‐Tremblay, Pierre‐Louis; Arndtsen, Bruce A. 3 of 3

Abstract

We describe here the development of a visible light driven nickel carbonylation catalyst. The combination of the large bite‐angle Xantphos ligand with nickel(0) generates a catalyst capable of activating alkyl halides toward carbonylation at ambient temperature in the presence of blue light irradiation, and the reductive elimination of high energy acid chloride products. Unlike classical carbonylations, where the coordination of carbon monoxide inhibits the reactivity of earth abundant nickel catalysts, a CO‐associated nickel is found to be the active catalyst in the reaction. Coupling the build‐up of acid chlorides with nucleophile addition can be used to access various amides, esters and thioesters, including those of sterically encumbered substrates or with metal‐reactive functionalities. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Angewandte Chemie International Edition. 2023/03, Vol. 62, Issue 10, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2023
  • ISSN:1433-7851
  • DOI:10.1002/anie.202213297
  • Accession Number:161985128
  • Copyright Statement:Copyright of Angewandte Chemie International Edition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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