JOURNAL ARTICLE

Halogen‐Atom Transfer Enabled Catalytic Enantioselective Coupling to Chiral Trifluoromethylated Alkynes via Dual Nickel and Photocatalysis.

  • Published In: Angewandte Chemie International Edition, 2024, v. 63, n. 28. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lu, Shanya; Hu, Zihao; Wang, Dong; XU, Tao 3 of 3

Abstract

With halogen‐atom transfer as an effective tool, a novel catalytic enantioselective protocol to generate chiral trifluoromethylated alkynes has been established by a cooperative photoredox and nickel catalysis system, providing a straightforward and modular route to access this type of product in good yields and enantioselectivities. The halogen‐atom transfer process is essential for the reaction and this novel strategy offers another promising way to utilize alkyl halides with highly negative reduction potentials. It firstly expands nickel‐catalyzed asymmetric reductive cross‐couplings of organohalides from the traditional single‐electron transfer to halogen‐atom transfer. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Angewandte Chemie International Edition. 2024/07, Vol. 63, Issue 28, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2024
  • ISSN:1433-7851
  • DOI:10.1002/anie.202406064
  • Accession Number:178178127
  • Copyright Statement:Copyright of Angewandte Chemie International Edition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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