JOURNAL ARTICLE

Electrochemical Umpolung of C−H Nucleophiles Bearing Three Electron‐Withdrawing Groups to Trigger Radical 1,2‐Alkylarylations of Allylic Alcohols.

  • Published In: Advanced Synthesis & Catalysis, 2025, v. 367, n. 9. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Li, Qibin; Hu, Die; Xu, Kun; Zeng, Chengchu 3 of 3

Abstract

The electrochemical catalyst‐free generation of carbon radicals bearing three electron‐withdrawing groups from the corresponding C−H nucleophiles remains unexplored. To this end, we report a direct electro‐oxidation strategy to access these electrophilic carbon radicals under catalyst‐free conditions. Enabled by this strategy, the radical 1,2‐alkylarylations of allylic alcohols was realized, affording β‐quaternary ketones with high functional group compatibility. This protocol is operationally simple and also easy to scale up. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Advanced Synthesis & Catalysis. 2025/05, Vol. 367, Issue 9, p1
  • Document Type:Article
  • Subject Area:Chemistry
  • Publication Date:2025
  • ISSN:1615-4150
  • DOI:10.1002/adsc.202401522
  • Accession Number:185185956
  • Copyright Statement:Copyright of Advanced Synthesis & Catalysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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