JOURNAL ARTICLE

NMR metabolomics analysis of Escherichia coli cells treated with Turkish propolis water extract reveals nucleic acid metabolism as the major target.

  • Published In: Journal of Applied Microbiology, 2023, v. 134, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Elgin, E Sonay; Çatav, Ş Serter; Babayeva, Anara; Kim, Hakbeom; Dibek, Esra; Çöl, Bekir; Chae, Young Kee; Kıvrak, İbrahim 3 of 3

Abstract

This article investigates the antibacterial mechanism of Turkish propolis water extract (PWE) against Escherichia coli BW25113 using nuclear magnetic resonance (NMR)-based metabolomics. The study identified 52 metabolites whose levels were altered by sub-lethal PWE concentrations, with purine metabolism being the most significantly affected pathway, indicating inhibition of nucleotide biosynthesis. Additionally, PWE treatment induced oxidative, acid, and osmotic stresses in E. coli, contributing to DNA damage and growth inhibition. These findings provide insight into the collective antibacterial effects of propolis’s bioactive compounds and may inform the development of natural product-based therapies against antibiotic-resistant bacteria.

Additional Information

  • Source:Journal of Applied Microbiology. 2023/01, Vol. 134, Issue 1, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxac031
  • Accession Number:162823926
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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