JOURNAL ARTICLE

(133) Investigating Actinidin as a Potential Collagenase on Human Peyronie's Disease Cells.

  • Published In: Journal of Sexual Medicine, 2024. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Feng, K; Kiattiburut, W; Hickling, D; Burton, J; Campbell, J 3 of 3

Abstract

This article investigates the enzyme actinidin, derived from kiwi, as a potential collagenase treatment for Peyronie's Disease (PD), a connective tissue disorder causing penile curvature due to collagen-rich plaques. The study assessed actinidin's dose-dependent effects on human PD fibroblast cells, finding that low concentrations (1 mg/mL) significantly reduced collagen, while higher doses (above 15 mg/mL) exhibited cytotoxicity and disrupted cell membrane integrity. The authors suggest limiting treatment to doses below 10 mg/mL and propose further research on actinidin's molecular mechanisms and animal model effects. This research is notable given the lack of available FDA-approved collagenase treatments for PD in Canada.

Additional Information

  • Source:Journal of Sexual Medicine. 2024/01, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2024
  • ISSN:1743-6095
  • DOI:10.1093/jsxmed/qdae001.127
  • Accession Number:175495854
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