JOURNAL ARTICLE

Efficient topical treatments of cutaneous lupus erythematosus: a systematic review and network -meta-analysis.

  • Published In: Clinical & Experimental Dermatology, 2025, v. 50, n. 1. P. 21 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Fukasawa, Takemichi; Yoshizaki-Ogawa, Asako; Enomoto, Atsushi; Miyagawa, Kiyoshi; Sato, Shinichi; Yoshizaki, Ayumi 3 of 3

Abstract

This article focuses on a systematic review and network meta-analysis (NMA) evaluating the efficacy of topical treatments for cutaneous lupus erythematosus (CLE), a dermatological manifestation of lupus erythematosus. Analyzing seven randomized controlled trials involving 231 participants, the study found that nicotinamide 4%, clobetasol 0.05%, nicotinamide 2%, and tacrolimus 0.1% significantly improved disease severity as measured by the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI). The findings support CLASI as an appropriate clinical outcome measure for CLE treatment trials and highlight these topical agents as evidence-based options for managing CLE. Limitations include a scarcity of quality-of-life data and potential biases due to language restrictions and publication factors.

Additional Information

  • Source:Clinical & Experimental Dermatology. 2025/01, Vol. 50, Issue 1, p21
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2025
  • ISSN:0307-6938
  • DOI:10.1093/ced/llae236
  • Accession Number:182414720
  • Copyright Statement:Copyright of Clinical & Experimental Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.