The Role of Cell-Based Therapies in Acute Burn Wound Skin Repair: A Review.

This article focuses on tissue engineering solutions for skin repair, particularly the development and clinical application of cell-based therapies for burn wounds. It reviews the sources of cells used—autologous and allogeneic keratinocytes, fibroblasts, melanocytes, and pluripotent stem cells—and discusses their manipulation, delivery methods, and timing for optimal clinical use. The article highlights challenges such as achieving site-specific, full-thickness skin regeneration, reducing donor site morbidity, and improving scar outcomes, while noting advances including point-of-care cell harvesting and emerging 3D bioprinting technologies. It emphasizes the importance of integrating these therapies within clinical care pathways to enhance wound healing and long-term skin function.