The role of the combination of (zinc and vitamin E) on the ameliorating of redox status in male infertility.

Background: Countries have different rates of infertility. About 25% of married couples experience infertility, and it has been shown that male issues account for about 50% of infertility cases. Numerous systems, including the immunological, reproductive, and skin systems, depend critically on zinc and vitamin E. Men with infertility issues frequently have low amounts of zinc and vitamin E, which can result in a redox imbalance. when it comes to infertility in men. Male infertiles have an imbalance in their oxidative status. The goal of the study was to treat the infertile males by improving their redox status through the use of zinc and vitamin E together. Patients and methods: Fifty infertile males participated in a three-month long trial in which they were given a mixture of 50 mg of zinc and 400 IU of vitamin E once daily. For infertile men, tests for glutathione (GSH), malondialdehyde (MDA), semen analysis, and clinical examination were performed. Except for the semen analysis, which was performed prior to therapy in order to confirm the male patient's sterility, all of them were accomplished both before and after treatment. Results: The study's findings demonstrated that, in comparison to the normal control group, the infertile group had significantly lower semen parameters. Additionally, prior to therapy, the infertile group had a much higher level of MDA and a significantly lower concentration of GSH than the control group. On the other hand, following therapy, the treated group's concentration of GSH increased significantly and its level of MDA decreased significantly as compared to the infertile group. This study conclude the combination of zinc and vitamin E is considered as an important agent in treatment of disturbance in redox status in the infertile men. [ABSTRACT FROM AUTHOR]