JOURNAL ARTICLE

Coprococcus protects against high-fat diet-induced nonalcoholic fatty liver disease in mice.

  • Published In: Journal of Applied Microbiology, 2024, v. 135, n. 6. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lu, Kaikai; Zhou, Yimeng; He, Lei; Li, Ya; Shahzad, Muhammad; Li, Dongmin 3 of 3

Abstract

This article focuses on the identification and evaluation of Coprococcus, a gut bacterium, as a potential probiotic for the prevention and treatment of nonalcoholic fatty liver disease (NAFLD). Clinical analysis of fecal samples from 44 NAFLD patients and 41 healthy controls revealed a significant reduction of Coprococcus in NAFLD patients. Subsequent animal experiments demonstrated that oral administration of Coprococcus in mice fed a high-fat diet effectively reduced liver lipid accumulation, inflammation, and fibrosis, showing probiotic effects comparable to Lactobacillus rhamnosus GG (LGG), a known beneficial strain. These findings suggest that Coprococcus may serve as a promising probiotic candidate for NAFLD management, although further research is needed to confirm its efficacy across diverse populations.

Additional Information

  • Source:Journal of Applied Microbiology. 2024/06, Vol. 135, Issue 6, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2024
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxae125
  • Accession Number:178159281
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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