Do Novel Nonexercise and Nondrug Treatments Improve Global Cognition in Parkinson's Disease Patients? A Systematic Review and Bayesian Analysis.

  • Published In: European Journal of Neuroscience, 2025, v. 61, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Tang, Yingle; He, Peikun; Li, Yanyi; Ma, Guixian; Zhang, Yuhu; Wang, Lijuan; Nie, Kun 3 of 3

Abstract

This Bayesian network meta‐analysis method was used to assess the effect of novel treatments on global cognition in patients with Parkinson's disease (PD). We searched randomized controlled trials from PubMed, Cochrane Library, Web of Science and Embase to investigate novel treatments for global PD cognition until April 10, 2024. Effect size measures were standardized mean differences with 95% confidence intervals. We included 13 studies investigating traditional paper‐and‐pencil cognitive training, modified cognitive training (MCT), repetitive transcranial magnetic stimulation (rTMS), rTMS plus MCT, Mediterranean diet, speech therapy, transcranial direct current stimulation (tDCS) and tDCS plus MCT. Comparisons between novel treatments and the control group revealed the following findings: Mediterranean diet (1.25, 0.74–1.76), rTMS plus MCT (0.82, 0.13–1.52), rTMS (0.42, 0.08–0.76) and MCT (0.34, 0.03–0.66) exhibited statistically significant improvements in global cognition in patients with PD, while the remaining treatments did not reveal significant differences. To conclude, the Mediterranean diet, rTMS, MCTs and rTMS plus MCT could effectively improve global cognition in patients with PD. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:European Journal of Neuroscience. 2025/02, Vol. 61, Issue 3, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2025
  • ISSN:0953-816X
  • DOI:10.1111/ejn.70008
  • Accession Number:184016231
  • Copyright Statement:Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.