JOURNAL ARTICLE

(113) A Novel 3D Cellular Model for Peyronie's Disease Treatment Screening: PD.SPHERE.

  • Published In: Journal of Sexual Medicine, 2024. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kiattiburut, W; Feng, K; Burton, J; Campbell, J 3 of 3

Abstract

The article focuses on the development and preliminary evaluation of PD. SPHERE, a novel three-dimensional (3D) cellular model for Peyronie's disease (PD) treatment screening. Cultured from human PD fibroblasts using a micro-gravity method, PD. SPHERE better replicates the complex cellular environment of PD plaques compared to traditional monolayer and animal models. Initial testing with the enzyme actinidin showed significant changes in spheroid morphology and cellular composition, suggesting the model's utility in assessing treatment effects. The study highlights PD. SPHERE's potential for personalized therapy development and high-throughput screening, while noting the need for further research on gene expression and immunological responses to validate its pathophysiological relevance.

Additional Information

  • Source:Journal of Sexual Medicine. 2024/01, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2024
  • ISSN:1743-6095
  • DOI:10.1093/jsxmed/qdae001.107
  • Accession Number:175495834
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