JOURNAL ARTICLE

Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 7. P. 683 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wataru Kadowaki; Ryo Miyata; Sayaka Mizuno; Misa Fujinami; Yoshizumi Sato; Shigenori Kumazawa 3 of 3

Abstract

This article focuses on the isolation and anti-inflammatory evaluation of prenylated acetophenones from the roots of Calendula officinalis, a medicinal plant in the Asteraceae family. Using bioassay-guided fractionation, researchers identified two compounds—one novel prenylated acetophenone (methyl (E)-4-(3-acetyl-2,6-dihydroxyphenyl)-2-methylbut-2-enoate) and a known analog—both of which significantly inhibited lipopolysaccharide-stimulated nitric oxide (NO) production in murine J774.1 macrophage cells without cytotoxicity. These compounds demonstrated approximately twofold greater inhibitory activity on NO production compared to the positive control, suggesting potential suppression of inducible NO synthase expression. The study highlights the roots of C. officinalis as a promising natural source of anti-inflammatory agents.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2023/07, Vol. 87, Issue 7, p683
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbad042
  • Accession Number:164742873
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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