Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain.

This article investigates the effects of the flavonoids quercetin and fisetin, alone and in combination with the neuropathic pain medications pregabalin and gabapentin, on neuropathic pain in a rat model induced by chronic constrictive injury (CCI). The study found that quercetin and fisetin at doses of 10 and 20 mg/kg produced significant antiallodynic (pain-relieving) effects, and when combined with lower doses of pregabalin (15 mg/kg) or gabapentin (50 mg/kg), these flavonoids enhanced and prolonged the analgesic effects compared to the drugs alone. The combinations achieved similar or greater pain relief than higher doses of pregabalin or gabapentin, suggesting potential dose reduction benefits. Locomotor activity assessments indicated that these effects were not due to sedation. The findings support the potential use of quercetin and fisetin as adjunctive agents to improve neuropathic pain management, though further studies are recommended to confirm these results.