Molecular Mechanisms from Insulin-Mimetic Effect of Vitamin D: Treatment Alternative in Type 2 Diabetes Mellitus.

  • Published In: Cuestiones de Fisioterapia, 2025, v. 54, n. 3. P. 2023 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Nandikola, Jaya Raju; khirwadkar, Praveen; Ragini, V.; R, Manju; Ranjani, V. Asha; Peter, T.; Tiwari, Gaurav; Devarakonda, Surya 3 of 3

Abstract

Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disorder characterized by insulin resistance and beta-cell dysfunction. Recent research highlights the role of vitamin D in glucose homeostasis and its potential insulin-mimetic effects. This review explores the molecular mechanisms by which vitamin D enhances insulin sensitivity, preserves beta-cell function, and modulates inflammatory and oxidative stress pathways. Vitamin D influences insulin receptor expression activates the PI3K/AKT pathway, and regulates PPAR-γ, thereby improving glucose uptake and metabolic control. Additionally, vitamin D exerts anti-inflammatory and antioxidant effects, reducing cytokine-induced insulin resistance. Clinical studies suggest that vitamin D supplementation may serve as an adjunctive therapy for T2DM, although further research is needed to determine optimal dosing and patient-specific responses. This review underscores the potential of vitamin D as a promising alternative or complementary approach in the management of T2DM. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Cuestiones de Fisioterapia. 2025/09, Vol. 54, Issue 3, p2023
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2025
  • ISSN:1135-8599
  • Accession Number:186684065
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